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KMID : 0388019950060010031
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Korean Journal Gynecologic Oncology and Colposcopy
1995 Volume.6 No. 1 p.31 ~ p.37
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An Evaluation on 1,000 Cases of Squamous Intraepithelial Lesion and Squamous Cell Carcinoma Histologically Confirmed
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김희수
백희수/손찬우/이기헌/심재욱/박종택/전종수/박인서/김희숙
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Abstract
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The cervical smears represent the most effective techinque to detect and prevent cancer of the uterine cervix, its false-negative rate is still a reason of concern among pathologists and gynecologists.
This study was performed to determine the false-negative rate in cervical smears and to evaluate the causes for false negatives.
The histologically confirmed consecutive 1,000 cases of Squamous Intraepithelial Lesion(SIL) and Squamous Cell Carcinoma(SCC) of the uterine cervix from the surgical files of Department of Pathology, Cheil General Hospital. From January 1992 to
June
1993 were collected.
All cervical smears of 1,000 cases, which obtained prior to pathologic diagnosis made, were evaluated based on cyto-histologic correlation. The false negatives were identified and cervical smears were reviewed. The for false negatives were
analysed
as
well.
@ES The results are as follow:
@EN 1. Histologic diagnoses of 1,000 cases include 252 cases of Low grade SIL(LSIL), 484 cases of High SIL(HSIL) and 284 cases of SCC.
2. 60 cases were identified as false negatives. The false-negative rate was 6%(60/1000). Those 60 cases of false negatives were 31 cases(51.7%) of LSIL, 23 cases(38.3%) of HSIL and cases 6 cases(10%) of SCC.
3. False-negative rate were 12.3%(31/252) of LSIL, 4.8%(23/484) 0f HSIL and 2.1%(6/284) of SCC.
4. In 58 of 60 cases reviewed, the sampling error were 75.9%(44/58) and screening error were 24.1%(14/58).
5. Sampling error were 65.9%(29/44) of LSIL, 31.8%(14/44) of HSIL and 2.3%(1/44) of SCC.
6. Screening error were 4 cases of LSIL, 6 cases of HSIL and 4 of SCC. In conclusion, the major reason of false negatives was sampling error and the major lesion of false negativity and sampling error was LSIL. These findings suggest that LSIL
should
require further investigation by colposcopy, cervicography and HPV Test in order to reduced the false-negative rate. The supporting of sufficient clinical informations, good supervision and training of cytotechnologist, use of automated cytologic
screening system in order to reduced false-negative rate in HSIL and SCC.
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KEYWORD
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